Recombinant Mouse Grb14 Protein, Myc/DDK-tagged

• Cat.No.: Grb14-3303M
• Product Overview: Purified recombinant protein of mouse full-length growth factor receptor bound protein 14 (Grb14), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
• Molecular Mass: 60.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Grb14 growth factor receptor bound protein 14 [ Mus musculus (house mouse) ]
• Official Symbol: Grb14
• Synonyms: GRB14; growth factor receptor bound protein 14; growth factor receptor-bound protein 14; GRB14 adapter protein; AI505286
• Gene ID: 50915
• mRNA Refseq: NM_016719
• Protein Refseq: NP_057928
• UniProt ID: Q9JLM9