Recombinant Mouse Gfra2

• Cat.No.: Gfra2-1742M

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• Description: Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons. GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR). GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse GFRα-2 is Mr 74 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 [ Mus musculus ]
• Synonyms: Gfra2; glial cell line derived neurotrophic factor family receptor alpha 2; GFR alpha 2; GFR alpha-2
• Gene ID: 14586
• mRNA Refseq: NM_008115
• Protein Refseq: NP_032141
• UniProt ID: O08842
• Chromosome Location: 14 D3-E1
• Function: receptor activity