GFRA2
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Official Full Name
GDNF family receptor alpha 2 -
Overview
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GFRA2;GDNF family receptor alpha 2;GDNF family receptor alpha-2;GDNFRB;NTNRA;RETL2;TRNR2;GDNFR-beta;NTNR-alpha;GFR-alpha 2;RET ligand 2;GDNFR-alpha-2;GDNF receptor beta;neurturin receptor alpha;TRN receptor, GPI-anchored;PI-linked cell-surf
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Rhesus macaque
- Rat
- HEK293
- Mammalian cells
- Mammalian Cell
- CHO
- Human Cell
- E.coli
- HEK293F
- His
- Fc
- Non
- His&Fc&Avi
- His&Fc
Involved Pathway
GFRA2 involved in several pathways and played different roles in them. We selected most pathways GFRA2 participated on our site, such as Axon guidance,Developmental Biology,NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NCAM1 interactions | NRTN,PSPN,GFRA4,GDNF,COL9A1B,COL9A1A,GFRA1 |
| Developmental Biology | EVL,EPHA10,MED16,KALRNB,EFNA1B,RHOB,SPTBN1,AP2A1,EFNA1,SCN2A |
| NCAM signaling for neurite out-growth | COL9A1B,NRTN,ST8SIA2,PSPN,COL9A1A,GFRA1,GFRA4,GDNF |
| Axon guidance | PAK4,PLXNA3,MYL12A,CHL1,EPHA4,SEMA4C,NTN1,DUSP10,RHOA,PEA15 |
Protein Function
GFRA2 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA2 itself. We selected most functions GFRA2 had, and list some proteins which have the same functions with GFRA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glial cell-derived neurotrophic factor receptor activity | GFRA1,GFRA4 |
Interacting Protein
GFRA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA2.
GFRA2 Related Signal Pathway
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