Recombinant Mouse Gfra1 protein, His & GST-tagged

• Cat.No.: Gfra1-1855M
• Product Overview: Recombinant Mouse Gfra1 aa. (Glu239~Asp350 (Accession # P97785)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Mouse
• Source: E.coli
• Tag: GST&His
• Protein Length: Glu239~Asp350
• Description: This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 42.4kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 4.6

Gene Information

• Gene Name: Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 [ Mus musculus (house mouse) ]
• Official Symbol: Gfra1
• Synonyms: Gfra1; glial cell line derived neurotrophic factor family receptor alpha 1; AU042498; GDNF family receptor alpha-1; GDNFR-alpha-1; GFR alpha-1; TGF-beta-related neurotrophic factor receptor 1
• Gene ID: 14585
• mRNA Refseq: NM_001285457.2
• Protein Refseq: NP_001272386.1
• UniProt ID: P97785