Recombinant Mouse Gcsam Protein, Myc/DDK-tagged

• Cat.No.: Gcsam-3177M
• Product Overview: Purified recombinant protein of mouse full-length germinal center associated, signaling and motility (Gcsam), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
• Molecular Mass: 21 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Gcsam germinal center associated, signaling and motility [ Mus musculus (house mouse) ]
• Official Symbol: Gcsam
• Synonyms: Gcsam; germinal center associated, signaling and motility; M17; Gcet; Gcet2; M17-L; germinal center-associated signaling and motility protein; germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2
• Gene ID: 14525
• mRNA Refseq: NM_001159297
• Protein Refseq: NP_001152769
• UniProt ID: Q6RFH4