Recombinant Mouse Foxl2 Protein, Myc/DDK-tagged

• Cat.No.: Foxl2-3075M
• Product Overview: Purified recombinant protein of mouse full-length forkhead box L2 (Foxl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 39.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Foxl2 forkhead box L2 [ Mus musculus (house mouse) ]
• Official Symbol: Foxl2
• Synonyms: FOXL2; forkhead box L2; forkhead box protein L2; P-Frk; pituitary forkhead factor; putative transcription factor foxl2; BPES; Pfrk; PINTO; AU045128
• Gene ID: 26927
• mRNA Refseq: NM_012020
• Protein Refseq: NP_036150
• UniProt ID: O88470