Recombinant Mouse Fgd4 Protein, Myc/DDK-tagged

• Cat.No.: Fgd4-2992M
• Product Overview: Purified recombinant protein of mouse full-length FYVE, RhoGEF and PH domain containing 4 (Fgd4), transcript variant alpha, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 86.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fgd4 FYVE, RhoGEF and PH domain containing 4 [ Mus musculus (house mouse) ]
• Official Symbol: Fgd4
• Synonyms: FGD4; FYVE, RhoGEF and PH domain containing 4; FYVE, RhoGEF and PH domain-containing protein 4; frabin; Fgd1-related F-actin-binding protein; actin filament-binding protein frabin; Frabp; ZFYVE6; 9030023J02Rik; 9330209B17Rik
• Gene ID: 224014
• mRNA Refseq: NM_139232
• Protein Refseq: NP_631978
• UniProt ID: Q91ZT5