Recombinant Mouse Eif2ak3 Protein, Myc/DDK-tagged

• Cat.No.: Eif2ak3-2772M
• Product Overview: Purified recombinant protein of mouse full-length eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome.
• Molecular Mass: 125.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Eif2ak3
• Synonyms: EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; Pek; Perk; AI427929
• Gene ID: 13666
• mRNA Refseq: NM_010121
• Protein Refseq: NP_034251
• UniProt ID: Q7TQC8