Recombinant Mouse Ednrb Protein, Myc/DDK-tagged

• Cat.No.: Ednrb-2730M
• Product Overview: Purified recombinant protein of mouse full-length endothelin receptor type B (Ednrb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 49.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ednrb endothelin receptor type B [ Mus musculus (house mouse) ]
• Official Symbol: Ednrb
• Synonyms: EDNRB; endothelin receptor type B; endothelin B receptor; ET-BR; piebald; endothelin receptor non-selective type; s; ETb; ET-B; ET> B< ETR-b; Sox10m1; AU022549
• Gene ID: 13618
• mRNA Refseq: NM_001136061
• Protein Refseq: NP_001129533
• UniProt ID: P48302