EDNRB
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Official Full Name
endothelin receptor type B -
Overview
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] -
Synonyms
EDNRB;endothelin receptor type B;ETB;ET-B;ETBR;ETRB;HSCR;WS4A;ABCDS;ET-BR;HSCR2;endothelin B receptor;endothelin receptor non-selective type
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- Mus musculus
- Coturnix japonica
- Sus scrofa (Pig)
- Bovine
- Oryctolagus cuniculus (Rabbit)
- Dog
- Horse
- E.coli
- Mammalian Cells
- Human Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Fc
- Non
- GST
- DDK&Myc
- Avi&Fc&His
Involved Pathway
EDNRB involved in several pathways and played different roles in them. We selected most pathways EDNRB participated on our site, such as Arf6 trafficking events,Calcium signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endothelin | CALCA,CALCRL,EDNRA,ECE1,RAMP1,CNN1,EDN1,MYL1 |
| Class A/1 (Rhodopsin-like receptors) | OPN1LW1,AGTR1,GPR68,RGS1,CCL27,NMBA,NPS,CYSLTR1,CCR8,NPFFR2 |
| GPCR ligand binding | CHRM5,CCR8,LPAR2A,UTS2,OPN1LW,DRD4,S1PR3,OPN5,SSTR4,FPR-RS6 |
| Arf6 trafficking events | EXOC3,CPE,JUP,SPAG9,ADRB2,EXOC1,EXOC5,PTBP3,CTNND1,CHRM2 |
| Calcium signaling pathway | PPIFB,CAMK2D2,ORAI1,ADRA1D,RYR1,SPHK2,ERBB3,TACR3L,CAMK2G,P2RX3 |
| Endothelins | CYSLTR1,EDNRA,COL1A2,EDN3,COL3A1,EDN1,EDN2 |
| G alpha (q) signalling events | NPSR1,DGKA,OPN4B,EDNRAB,CHRM5,PROKR1,ABHD6B,CCK,ARHGEF25,ANXA1B |
| GPCR downstream signaling | RGS19,EDN3,GPR4,OPN4B,DCLRE1B,CXCR6,ADORA2B,CGA,RGS21,ARHGAP4A |
Protein Function
EDNRB has several biochemical functions, for example, endothelin receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRB itself. We selected most functions EDNRB had, and list some proteins which have the same functions with EDNRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone binding | GCGR,GIPR,AGTR2,CRHR2,RXFP2,GHSR,MC3R,PTH1RA,PTH1RB,INHBA |
| protein binding | FBXO5,RGS19,EOMESA,ATP6V0A4,SMAD3B,LOXL4,SNCA,APOB,THBS4,DNAJB11 |
| endothelin receptor activity | EDNRA,EDNRBA,EDNRAA,EDNRAB |
Interacting Protein
EDNRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRB here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRB.
EDN1
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References
- Wang, C; Wang, HY; et al. Genome-wide analysis reveals artificial selection on coat colour and reproductive traits in Chinese domestic pigs. MOLECULAR ECOLOGY RESOURCES 15:414-424(2015).
- Moore, SW; Zaahl, M; et al. Clinical and genetic correlations of familial Hirschsprung's disease. JOURNAL OF PEDIATRIC SURGERY 50:285-288(2015).
