Recombinant Mouse Dtnbp1 Protein, Myc/DDK-tagged

• Cat.No.: Dtnbp1-2672M
• Product Overview: Purified recombinant protein of mouse full-length dystrobrevin binding protein 1 (Dtnbp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
• Molecular Mass: 39.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dtnbp1 dystrobrevin binding protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Dtnbp1
• Synonyms: DTNBP1; dystrobrevin binding protein 1; dysbindin; sandy; dysbindin-1; HPS7 protein homolog; dystrobrevin-binding protein 1; hermansky-Pudlak syndrome 7 protein homolog; sdy; AW048963; 5430437B18Rik
• Gene ID: 94245
• mRNA Refseq: NM_025772
• Protein Refseq: NP_080048
• UniProt ID: Q91WZ8