Recombinant Mouse Disc1 Protein, Myc/DDK-tagged

• Cat.No.: Disc1-2571M
• Product Overview: Purified recombinant protein of mouse full-length disrupted in schizophrenia 1 (Disc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 92.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Disc1 disrupted in schizophrenia 1 [ Mus musculus (house mouse) ]
• Official Symbol: Disc1
• Synonyms: DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog
• Gene ID: 244667
• mRNA Refseq: NM_174854
• Protein Refseq: NP_777279
• UniProt ID: Q811T9