DISC1
-
Official Full Name
disrupted in schizophrenia 1 -
Overview
interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia -
Synonyms
DISC1;disrupted in schizophrenia 1;disrupted in schizophrenia 1 protein;SCZD9;C1orf136;FLJ13381;FLJ21640;FLJ25311;FLJ41105;KIAA0457
Recombinant Proteins
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
DISC1 involved in several pathways and played different roles in them. We selected most pathways DISC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DISC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DISC1 has several biochemical functions, for example, kinesin binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DISC1 itself. We selected most functions DISC1 had, and list some proteins which have the same functions with DISC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex scaffold | MAGI3,TELO2,PKP2,AXIN1,GNB2L1,WWC1,AKAP13,MAGI1,SLC9A3R1,ITSN1 |
| protein binding | CD200R2,KRT18,TOMM20,TTC30B,ZMYND19,COPRS,PPAP2B,PAN2,GDNF,PCBP1 |
| kinesin binding | KIFAP3,SNCA,KIF18B,KCNC1,NEFH,MAPK8IP3,GOLSYN,KIF1B,KTN1,AP1G1 |
| protein complex binding | KRT8,EPHB1,SKIL,INS2,PPARA,CDH2,ANKRD54,PCSK2,NSF,CAV3 |
Interacting Protein
DISC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DISC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DISC1.
PCNT;TRAF3IP1;NDEL1
Resources
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References
- Bradshaw, NJ; Bader, V; et al. Aggregation of the Protein TRIOBP-1 and Its Potential Relevance to Schizophrenia. PLOS ONE 9:-(2014).
- El-Hassar, L; Simen, AA; et al. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. BIOLOGICAL PSYCHIATRY 76:476-485(2014).
