Recombinant Mouse CTGF protein, His-tagged

• Cat.No.: CTGF-393M
• Product Overview: Recombinant Mouse CTGF protein (Gln26-Ala348), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Lyophilized from 0.22 um filtered solution in Tris with Potassium glutamate and Arginine, pH7.0, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 37.3 kDa. The protein migrates as 37-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: 323
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: CTGF
• Official Symbol: CTGF
• Synonyms: CTGF; connective tissue growth factor; CCN family member 2; fibroblast inducible secreted protein; fibroblast inducible secreated protein; hypertrophic chondrocyte-specific protein 24; hypertrophic chondrocyte-specific gene product 24; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); Ccn2; Hcs24; Fisp12; fisp-12
• Gene ID: 14219
• mRNA Refseq: NM_010217
• Protein Refseq: NP_034347
• UniProt ID: P29268