CTGF
-
Official Full Name
connective tissue growth factor -
Overview
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] -
Synonyms
CTGF;connective tissue growth factor;CCN2;NOV2;HCS24;IGFBP8;IBP-8;IGFBP-8;CCN family member 2;IGF-binding protein 8;hypertrophic chondrocyte-specific protein 24;insulin-like growth factor-binding protein 8
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Cattle
- Sheep
- Pig
- Chicken
- Rabbit
- HEK293
- E.coli
- C-His
- Mammalian Cell
- Wheat Germ
- Human Cell
- Sf9 Insect Cell
- Mammalian cells
- In Vitro Cell Free System
- Protein Conjugation
- His&Avi
- His
- Non
- Fc
- GST
- His&T7
- Flag
- His&GST
- His&Fc&Avi
Involved Pathway
CTGF involved in several pathways and played different roles in them. We selected most pathways CTGF participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZNF726,ZNF394,ZNF34,ZNF777,PSTPIP2,CDK9,ZNF23,NR1I2,ZNF10,ZNF596 |
| Hippo signaling pathway | FBXW11,CDH1,Fzd4,GSK3B,AXIN1,WNT10B,BIRC5,CTNNA3,BBC3,FZD6 |
| Fatty acid, triacylglycerol, and ketone body metabolism | PLIN2,MED16,CYP4A11,G0S2,ACAD11,PPARGC1B,ACOT11B,YAP1,CYP7A1,TIAM2 |
| Metabolism | PLIN2,KCNJ11,AQP1A.2,CDO1,MARCKSB,COX11,G0S2,FTCD,TMEM195,UCP2 |
| Metabolism of lipids and lipoproteins | GLTPD1,G0S2,PEMT,GRHL1,ACSF2,SLC25A20,FA2H,ARF3,ACOT12,DHCR24 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED6,GLIPR1,MED19,MED9,MED21,MED26,G0S2,MED23,MED31,MED7 |
| PPARA activates gene expression | GLIPR1,MED19,MED20,MTF1,GRHL1,MED25,MED22,MED10,MED9,CDK19 |
| Gene Expression | ZNF189,SNRNP25,C14orf166,NR5A1A,HNRNPH1,ZNF71,GLS2B,TAF1D,PAIP1,ZNF157 |
Protein Function
CTGF has several biochemical functions, for example, fibronectin binding,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTGF itself. We selected most functions CTGF had, and list some proteins which have the same functions with CTGF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | S1PR3,ILK,LAMB2,WISP1B,ANXA7,MMP14,FBN1,TSPAN8,CD151,CXADR |
| heparin binding | ADAMTS1,CXCL10,COL5A1,APPA,FGF1,CXCL6,ADAMTSL5,ITGAM,CTSG,AZU1 |
| insulin-like growth factor binding | ESM1,WISP1B,CYR61L1,HTRA1,IGFBP5A,WISP3,CTGFB,IGF1R,HTRA3,CTGFA |
| protein binding | GFI1B,BRD9,TCF4,SNRNP27,DERL1,NAPB,FLOT2,NUMBL,PVRL3,DES |
| protein C-terminus binding | ID1,PLEKHB1,PQBP1,KCNK3,STIP1,HSPB7,PFKM,FIGN,KPNA3,SAE1 |
| growth factor activity | NDR1,FGF18B,IL6,IL9,HBEGFA,BMP15,THPO,MSTN,INHBE,INHBC |
| fibronectin binding | SFRP2,LPA,PLEKHA2,SDC4,THBS1,IGFBP3,FBLN1,ITGA3,VEGFA,HSD17B12 |
Interacting Protein
CTGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTGF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTGF.
FN1;FGFR1OP;FGFR2;FGFR3;LIMS1;q81kk8_bacan;lonB;q81tk4_bacan;rpoB;gnd;nemA;mdtB;rnhA;q9wmx2-pro_0000037548;ITGA5
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References
- Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
- Gao, W; Cai, LT; et al. Anti-CTGF Single-Chain Variable Fragment Dimers Inhibit Human Airway Smooth Muscle (ASM) Cell Proliferation by Down-Regulating p-Akt and p-mTOR Levels. PLOS ONE 9:-(2014).
