Recombinant Mouse Ccdc115 Protein, Myc/DDK-tagged

• Cat.No.: Ccdc115-1986M
• Product Overview: Purified recombinant protein of mouse full-length coiled-coil domain containing 115 (Ccdc115), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 19.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ccdc115 coiled-coil domain containing 115 [ Mus musculus (house mouse) ]
• Official Symbol: Ccdc115
• Synonyms: CCDC115; coiled-coil domain containing 115; coiled-coil domain-containing protein 115; coiled-coil protein 1; Ccp1; 2310061I09Rik
• Gene ID: 69668
• mRNA Refseq: NM_027159
• Protein Refseq: NP_081435
• UniProt ID: Q8VE99