Recombinant Mouse Bone Morphogenetic Protein 6

• Cat.No.: Bmp6-27M
• Product Overview: Recombinant mouse bone morphogenetic protein-6 is expressed inNSO cells. An osteopenia protein belonging to the transforming growth factor-β (TGF-β) superfamily. BMP-6 has been shown to strongly induce phosphorylation and nuclear accumulation of Smad5. BMPs have also been shown to be involved in embryogenesis and morphogenesis of cells of osteoplastic lineage.

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• Description: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
• Form: Lyophilized.
• Formulation: Lyophilized from a 0.2 μm filtered solution of 35% ACN, 0.1% TFA, 50 μg BSA/μg BMP-6.
• Molar Mass: 48000Da.
• Biological Activity: ED50 = 50-150 ng/ml based on the ability to induce alkaline phosphatase expression in MC3T3-E1 Cells.
• Unit Definition: One unit is defined as the amount of enzyme that will phosphorylate 1.0 nmol GST-c-Jun (1-79) Substrate per min at 30°C, pH 7.5.
• Purity: ≥95% by SDS-PAGE.
• Storage: ≤ -70oC. Ship: Dry Ice Only.

Gene Information

• Gene Name: Bmp6 bone morphogenetic protein 6 [ Mus musculus ]
• Synonyms:
  Bmp6; bone morphogenetic protein 6; BMP-6; VG-1-related protein; D13Wsu115e; Vgr1
• Gene ID: 12161
• mRNA Refseq: NM_007556
• Protein Refseq: NP_031582
• UniProt ID: P20722
• Chromosome Location: 13 20.0 cM
• Pathway: Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway
• Function: BMP receptor binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity