Recombinant Mouse Amotl2 Protein, Myc/DDK-tagged

• Cat.No.: Amotl2-1614M
• Product Overview: Purified recombinant protein of mouse full-length angiomotin-like 2 (Amotl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 85.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Amotl2 angiomotin-like 2 [ Mus musculus (house mouse) ]
• Official Symbol: Amotl2
• Synonyms: Amotl2; angiomotin-like 2; Lc; MAS; Lccp; C79691; MASCOT; AW549739; mKIAA0989; angiomotin-like protein 2; Leman coiled-coil protein
• Gene ID: 56332
• mRNA Refseq: NM_019764
• Protein Refseq: NP_062738
• UniProt ID: Q8K371