Recombinant Mouse Alk Protein

• Cat.No.: Alk-15M
• Product Overview: Recombinant Mouse Alk(aa.19-1042) was expressed in HEK293.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Non
• Protein Length: aa.19-1042
• Description: Notum is an evolutionarily conserved 60 kDa secreted deacylase that regulates Wnt activity. It is tethered to the cell surface by binding to Glypican-like sulfated proteoglycans, and it functions as a Glypican-dependent Wnt inhibitor. Notum hydrolyzes the palmitoyl moiety from Wnt-3a, making the Wnt more hydrophilic and unable to bind to the Frizzled-8 receptor. It also induces the release of cell surface GPI-anchored proteins such as Glypican-3, Cadherin-13, and uPAR. Notum regulates head regeneration in planaria, head formation and neural induction in Xenopus, and long range activity of hedgehog proteins in Drosophila. It is up-regulated in some human hepatocellular carcinomas and colorectal cancers. Within amino acids 88-458, mouse Notum shares 92% and 99% aa sequence identity with human and rat Notum, respectively.
• Form: Each vial contains 50ug purified protein(1mg/ml) in PBS(pH7.4).
• Purity: >95%
• Applications: ELISA, WB, Immunogen
• Storage: Store at -80 centigrade, Avoid freeze / thaw cycle.

Gene Information

• Gene Name: Alk anaplastic lymphoma kinase [ Mus musculus ]
• Official Symbol: Alk
• Synonyms: ALK; anaplastic lymphoma kinase; ALK tyrosine kinase receptor; Tcrz; CD246
• Gene ID: 11682
• mRNA Refseq: NM_007439
• Protein Refseq: NP_031465
• UniProt ID: P97793