Recombinant Mouse Agtpbp1 Protein, Myc/DDK-tagged

• Cat.No.: Agtpbp1-1562M
• Product Overview: Purified recombinant protein of mouse full-length ATP/GTP binding protein 1 (cDNA clone MGC:79186 IMAGE:6848599), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.
• Molecular Mass: 168.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Agtpbp1 ATP/GTP binding protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Agtpbp1
• Synonyms: Agtpbp1; ATP/GTP binding protein 1; N; at; Ccp; pcd; CCP1; Nna1; atms; nmf243; 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; cytosolic carboxypeptidase 1; Purkinje cell degeneration; nervous system nuclear protein induced by axotomy protein 1; nuclear ATP/GTP-binding protein; EC 3.4.17.-
• Gene ID: 67269
• mRNA Refseq: NM_023328
• Protein Refseq: NP_075817
• UniProt ID: Q641K1