Recombinant Mouse Adamts7 protein, His-tagged

• Cat.No.: Adamts7-512M
• Product Overview: Recombinant Mouse Adamts7(Lys226~Pro437) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Protein Length: 226-437 a.a.
• Description: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing.
• Form: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Molecular Mass: 25.2 kDa
• AA Sequence: KWVET LVVADSKMVE YHGQPQVESY VLTIMNMVAG LFHDPSIGNP IHISIVRLII LEDEEKDLKI THHAEETLKN FCRWQKNINI KGDDHPQHHD TAILLTRKDL CASMNQPCET LGLSHVSGLC HPQLSCSVSE DTGMPLAFTV AHELGHSFGI QHDGTGNDCE SIGKRPFIMS PQLLYDRGIP LTWSRCSREY ITRFLDRGWG LCLDDRP
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Adamts7 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 [ Mus musculus ]
• Official Symbol: Adamts7
• Synonyms: ADAMTS7; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7; A disintegrin and metalloproteinase with thrombospondin motifs 7; COMPase; ADAMTS-7; ADAM-TS 7; metalloprotease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM-TS7; ADAMTS7B
• Gene ID: 108153
• mRNA Refseq: NM_001003911
• Protein Refseq: NP_001003911
• Chromosome Location: 9; 9 E3.1
• Function: hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding