Recombinant Mouse Abcc1 protein, His & T7-tagged

• Cat.No.: Abcc1-1458M
• Product Overview: Recombinant Mouse Abcc1 aa. (Arg1219~Ile1469 (Accession # O35379)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites.
• Source: E. coli
• Species: Mouse
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 31.7kDa.
• Protein length: Arg1219~Ile1469
• Endotoxin: <1.0EU per 1µg (determined by the LAL method).
• Purity: >95%
• Characteristic: The isoelectric point is 5.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Abcc1
• Synonyms: MRP; Mrp1; Mdrap; Abcc1a; Abcc1b; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; LTC4 transporter; leukotriene C(4) transporter; multiple drug resistance-associated protein; multidrug resistance-associated protein 1
• Gene ID: 17250
• mRNA Refseq: NM_008576.3
• Protein Refseq: NP_032602.1
• UniProt ID: O35379