Recombinant Monkey TNFRSF4 Protein, Fc-tagged, Alexa Fluor 647 conjugated

• Cat.No.: TNFRSF4-549RAF647
• Product Overview: Alexa Fluor 647 conjugated recombinant Rhesus TNFRSF4 (XP_001090870.1) (Met1-Ala216) was expressed with the Fc region of human IgG1 at the C-terminus.

Specification

• Species: Monkey
• Source: HEK293
• Tag: Fc
• Protein Length: Met1-Ala216， 426
• Description: OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
• Form: Lyophilized
• Molecular Mass: 47 kDa
• N-terminal Sequence Analysis: Leu 29
• Endotoxin: < 1.0 EU/ μg protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 647 via amines
  Excitation = 650 nm
  Emission = 668 nm
• Storage: Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: TNFRSF4 TNF receptor superfamily member 4 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: TNFRSF4
• Synonyms: TNFRSF4; TNF receptor superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4
• Gene ID: 699674
• mRNA Refseq: XM_001090870
• Protein Refseq: XP_001090870