Recombinant IAV NA Protein, His-tagged

• Cat.No.: NA-01I
• Product Overview: Recombinant IAV (A/Puerto Rico/8/1934) NA Protein (aa 36-454) with a 6xHis tag was expressed in 293 cell.

Specification

• Species: IAV
• Source: HEK293
• Tag: His
• ProteinLength: 36-454
• Description: Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
• Purity: ≥80%
• Applications: WB standard, antibody ELISA, Functional analysis, etc
• Storage: Keep it at 4oC if used within a month. For long term storage, split it into small aliquots and keep at -80oC. Avoid repeated freezing and thawing. The product will be expired one year after receiving if stored properly. Non-hazardous. No MSDS required.
• Concentration: 1 mg/mL
• Storage Buffer: Each vial contains 100 μg of purified protein in PBS.

Gene Information

• Gene Name: NA neuraminidase [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]
• Official Symbol: NA
• Synonyms: NA; neuraminidase
• Gene ID: 956530
• Protein Refseq: NP_040981
• UniProt ID: P03468