Recombinant Human ZNRF2, GST-tagged

• Cat.No.: ZNRF2-135H
• Product Overview: Recombinant human ZNRF2 (amino acid residues 1-242), with N-terminal GST, was expressed in E.coli.

Specification

• Description: The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including the regulated and targeted proteasome-dependent degradation of substrate proteins. Three classes of enzymes are involved in the process of ubiquitylation; activating enzymes (E1s), conjugating enzymes (E2s) and protein ligases (E3s). Zinc and Ring Finger protein 2 (ZNRF2) is a member of the Really Interesting New Gene (RING) E3 protein ligase family and cloning of the human gene was first described by Araki et al. (2001).
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
• Molecular Mass: ~50kDa
• Storage: 12 months at -70°C. Avoid multiple freeze/thaw cycles.
• Concentration: 0.5mg/ml
• Protein length: 1-242 a.a.

Gene Information

• Gene Name: ZNRF2 zinc and ring finger 2 [ Homo sapiens ]
• Official Symbol: ZNRF2
• Synonyms: ZNRF2; zinc and ring finger 2; E3 ubiquitin-protein ligase ZNRF2; RNF202; protein Ells2; RING finger protein 202; zinc finger/RING finger 2; zinc/RING finger protein 2
• Gene ID: 223082
• mRNA Refseq: NM_147128
• Protein Refseq: NP_667339
• MIM: 612061
• UniProt ID: Q8NHG8
• Chromosome Location: 7p15.1
• Function: ligase activity; metal ion binding; zinc ion binding