Recombinant Human ZCCHC12, His-tagged

• Cat.No.: ZCCHC12-211H
• Product Overview: ZCCHC12, 1-402aa, Human, His tag, E.coli

Specification

• Description: ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein , fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 47.8kDa (425aa)
• Protein length: 1-402aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: ZCCHC12 zinc finger, CCHC domain containing 12 [ Homo sapiens ]
• Official Symbol: ZCCHC12
• Synonyms: ZCCHC12; zinc finger, CCHC domain containing 12; zinc finger CCHC domain-containing protein 12; FLJ16123; paraneoplastic Ma antigen family member 7A; PNMA7A; SIZN; SIZN1; 2810028A01Rik; smad-interacting zinc finger protein 1
• Gene ID: 170261
• mRNA Refseq: NM_173798
• Protein Refseq: NP_776159
• MIM: 300701
• UniProt ID: Q6PEW1
• Chromosome Location: Xq24
• Pathway: Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
• Function: metal ion binding; nucleic acid binding; zinc ion binding