Recombinant Human YWHAG

• Cat.No.: YWHAG-12H
• Product Overview: Recombinant Human KCIP-1 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 247 amino acids (1-247) and having a molecular mass of 28 kDa. 14-3-3-gamma is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-247 a.a.
• Description: The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ and η that have been identified in mammals. The 14-3-3gamma, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
• Amino Acid Sequence: MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN.
• Physical Appearance: Sterile filtered colorless solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: 1 mg/ml solution containing 20mM Tris 7.5.
• Storage: Recombinant Human 14-3-3 Gamma although stable at 14°Cfor 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.

Gene Information

• Gene Name: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [ Homo sapiens ]
• Synonyms: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 14-3-3GAMMA; YWHAG; 14-3-3 gamma; KCIP-1; Protein kinase C inhibitor protein 1
• Gene ID: 7532
• mRNA Refseq: NM_012479
• Protein Refseq: NP_036611
• MIM: 605356
• UniProt ID: P61981
• Chromosome Location: 7q11.23
• Pathway: Cell cycle; Cell Cycle, Mitotic; Neurotrophin signaling pathway
• Function: insulin-like growth factor receptor binding; protein kinase C inhibitor activity; protein domain specific binding; protein kinase C binding