Recombinant Human YWHAB Protein, His-tagged

• Cat.No.: YWHAB-135H
• Product Overview: Recombinant Human YWHAB fused with His tag at N-terminal was expressed in Insect cells.

Specification

• Description: 14-3-3 alpha/beta is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 alpha/beta protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. 14-3-3-alpha/beta interacts with the TSC1-TSC2 dimer. The interaction required phosphorylation of TSC2 at Ser1210. Binding of 14-3-3-alpha/beta to TSC2 did not alter the interaction between TSC1 and TSC2, but it reduced the ability of the complex to inhibit phosphorylation of ribosomal protein S6 kinase impairing the ability of the complex to inhibit cell growth.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
• Molecular Mass: 32 kDa
• Purity: > 95%
• Applications: Western Blot
• Stability: 1 year at -70 centigrade from date of shipment.
• Storage: Store product at –70centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ml

Gene Information

• Gene Name: YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [ Homo sapiens ]
• Official Symbol: YWHAB
• Synonyms: YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, alpha polypeptide , YWHAA; 14-3-3 protein beta/alpha; 14 3 3 alpha; 14 3 3 beta; 14-3-3 alpha; protein 1054; brain protein 14-3-3, beta isoform; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; HS1; GW128; YWHAA; KCIP-1
• Gene ID: 7529
• mRNA Refseq: NM_003404
• Protein Refseq: NP_003395
• MIM: 601289
• UniProt ID: P31946