YWHAB
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Official Full Name
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide -
Overview
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms(Beta, Gamma, Epsilon, Eta, Zeta, Sigma and Tau/Phi) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cupshaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal transduction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders. -
Synonyms
YWHAB;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide;tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, alpha polypeptide , YWHAA;14-3-3 protein beta/alpha;14 3 3 alpha;14 3 3 beta;14-3-3 alpha;protein 1054;brain protein 14-3-3, beta isoform;protein kinase C inhibitor protein 1;protein kinase C inhibitor protein-1;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide;HS1;GW128;YWHAA;KCIP-1
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Insect Cells
- Mammalian Cells
- HEK293
- Yeast
- GST
- Non
- His
- Flag
- DDK
- Myc
- Avi
- Fc
- SUMO
Involved Pathway
YWHAB involved in several pathways and played different roles in them. We selected most pathways YWHAB participated on our site, such as Cell cycle,Oocyte meiosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | SPP1,TP53,PDGFB,LPAR2,PIK3CA,PRLR,FGF11,PIK3CB,RBL2,KLK1B4 |
| Cell cycle | ARPP19A,GADD45B,RBX1,MIS18BP1,E2F4,BUB1,GORASP2,BABAM1,CDKN1BA,H3F3D |
| Epstein-Barr virus infection | TRAF2,PTMA,BCL2,NFKBIA,TBK1,RBPJL,HLA-DPB1,SYK,IRF3,TRAF3 |
| Oocyte meiosis | CAMK2D2,PKMYT1,PPP3CC,PPP1CBL,CALM3,PPP2R5EB,CDC20,PPP2R5D,PPP3CB,MAD2L2 |
| Viral carcinogenesis | HDAC2,ATP6V0D1,HIST1H2BI,PXN,TRADD,GTF2B,PIK3CB,SRF,GTF2A1,HIST3H2BB-PS |
| Hepatitis B | PTK2B,IFNA21,MYD88,IFNA7,IFNA1,IFNA13,STAT2,APAF1,MAPK9,PIK3R5 |
| Hippo signaling pathway | LLGL1,TEAD4,CRB1,GSK3B,FZD2,WNT5A,Fzd4,BIRC5,TGFBR2,YWHAE |
Protein Function
YWHAB has several biochemical functions, for example, enzyme binding,histone deacetylase binding,phosphoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAB itself. We selected most functions YWHAB had, and list some proteins which have the same functions with YWHAB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | PUS7,CABYR,CUTA,HIST1H2AI,SIRT3,CTNNBL1,HIF1A,RXRA,ATF7,H2AFX |
| protein domain specific binding | ANGEL1,YWHAG,DDC,IL1B,ARFIP1,RXRA,UNC13A,IST1,TWIST2,GNAI3 |
| phosphoserine binding | PIN1,NEDD4,YWHAE |
| histone deacetylase binding | HEY2,CDC20,SP2,D7ERTD443E,MECP2,KPNA2,YY1,RAD9A,NCOR2,TRAF6 |
| protein complex binding | RPAIN,PFKP,STRN4,ANKRD32,TAB1,FGFR1,BAG3,PEX1,LCA5,ATG101 |
| protein C-terminus binding | TAE1,ATP1B1,AGO2,ATP2A2,YWHAQ,VAMP2,PXK,PHB2,PEX10,ERCC2 |
| protein binding | MTPAP,GTF2F2,INTS12,PCP4,PTPN4,ACACB,SCHIP1,SLC22A17,DDIT3,MRPL15 |
| transcription corepressor activity | GPS2,CRYM,TFAP2B,JUNB,ZNF274,TBL1Y,CIR1,ZBTB32,HIPK2,SKI |
| phosphoprotein binding | DPYSL3,TOX3,PRKCSH,MTOR,PITX2,GPRIN1,MID1,YWHAE,TBL2,SAG |
Interacting Protein
YWHAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAB here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAB.
RAF1;TSC2
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References
- Sun, YF; Liu, RR; et al. Genome-Wide Linkage Analysis and Association Study Identifies Loci for Polydactyly in Chickens. G3-GENES GENOMES GENETICS 4:1167-1172(2014).
- van Rijn, SJ; Riemers, FM; et al. Expression Stability of Reference Genes for Quantitative RT-PCR of Healthy and Diseased Pituitary Tissue Samples Varies Between Humans, Mice, and Dogs. MOLECULAR NEUROBIOLOGY 49:893-899(2014).
