Recombinant Human XIAP Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: XIAP-2775H
• Product Overview: XIAP MS Standard C13 and N15-labeled recombinant protein (NP_001158) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 56.7 kDa
• AA Sequence: MTFNSFEGSKTCVPADINKEEEFVE EFNRLKTFANFPSGSPVSASTLARA GFLYTGEGDTVRCFSCHAAVDRWQY GDSAVGRHRKVSPNCRFINGFYLEN SATQSTNSGIQNGQYKVENYLGSRD HFALDRPSETHADYLLRTGQVVDIS DTIYPRNPAMYSEEARLKSFQNWPD YAHLTPRELASAGLYYTGIGDQVQC FCCGGKLKNWEPCDRAWSEHRRHFP NCFFVLGRNLNIRSESDAVSSDRNF PNSTNLPRNPSMADYEARIFTFGTW IYSVNKEQLARAGFYALGEGDKVKC FHCGGGLTDWKPSEDPWEQHAKWYP GCKYLLEQKGQEYINNIHLTHSLEE CLVRTTEKTPSLTRRIDDTIFQNPM VQEAIRMGFSFKDIKKIMEEKIQIS GSNYKSLEVLVADLVNAQKDSMQDE SSQTSLQKEISTEEQLRRLQEEKLC KICMDRNIAIVFVPCGHLVTCKQCA EAVDKCPMCYTVITFKQKIFMSTRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: XIAP X-linked inhibitor of apoptosis [ Homo sapiens (human) ]
• Official Symbol: XIAP
• Synonyms: XIAP; X-linked inhibitor of apoptosis; API3, baculoviral IAP repeat containing 4, BIRC4; baculoviral IAP repeat-containing protein 4; hILP; X-linked IAP; IAP-like protein; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing 4; X-linked inhibitor of apoptosis protein; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; FLJ26913
• Gene ID: 331
• mRNA Refseq: NM_001167
• Protein Refseq: NP_001158
• MIM: 300079
• UniProt ID: P98170

Reviews

03/09/2021

With their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of XIAP protein and its biological significance.

06/23/2018

In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.

10/28/2017

The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of XIAP protein.

Q&As

Are there any clinical conditions associated with XIAP mutations?

Yes, mutations in XIAP are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare immunodeficiency disorder.

Are there any ongoing clinical trials involving XIAP-targeted therapies?

Yes, several clinical trials are investigating XIAP-targeted therapies for cancer, autoimmune diseases, and immunodeficiency disorders.

Can XIAP inhibitors be used to treat cancer?

XIAP inhibitors are being explored as potential treatments for cancer to sensitize cancer cells to apoptosis-inducing therapies.

How can XIAP be targeted for clinical applications?

XIAP can be targeted using small molecule inhibitors and gene therapy to modulate apoptosis in various diseases.

In what way can XIAP be linked to autoimmune diseases?

Dysregulation of XIAP has been associated with autoimmune diseases, and its modulation may be a therapeutic strategy in such conditions.