Recombinant Human X-linked Inhibitor Of Apoptosis, GST-tagged

• Cat.No.: XIAP-1503H
• Product Overview: Recombinant full-length human XIAP was expressed by baculovirus inSf9insect cells using a C-terminal GST tag. MW = 84 kDa.

Specification

• Cat. No.: XIAP-1503H
• Description: XIAP is a member of a family of proteins which inhibit apoptosis and act as mammalian cell-death suppressors. XIAP inhibits at least 2 members of the caspase family of cell-death proteases, caspase-3 and caspase-7. In addition, XIAP inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Furthermore, XIAP can mediate protection of cells from apoptosis by utilizing both a JNK1 activation pathway that involves ILPIP and a caspase inhibition pathway that is independent of ILPIP. Disruption of the XIAP gene in human colon cancer cells can enhance sensitivity of these cells to exogenously added TRAIL suggesting that XIAP is a nonredundant modulator of TRAIL-mediated apoptosis.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: XIAP X-linked inhibitor of apoptosis [ Homo sapiens ]
• Synonyms: XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA; XLP2; BIRC4; baculoviral IAP repeat-containing protein 4; OTTHUMP00000196392; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; E3 ubiquitin-protein ligase XIAP; Inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein; X-linked IAP; IAP-like protein; HILP; IAP3; EC 6.3.2.-; OTTHUMP00000023975; hILP
• Gene ID: 331
• mRNA Refseq: NM_001167
• Protein Refseq: NP_001158
• MIM: 300079
• UniProt ID: P98170
• Chromosome Location: Xq25
• Pathway: Apoptosis; Focal adhesion; NOD-like receptor signaling pathway; Pathways in cancer; Small cell lung cancer; Ubiquitin mediated proteolysis
• Function: caspase inhibitor activity; ligase activity; metal ion binding; peptidase inhibitor activity; protein binding; zinc ion binding