Recombinant Human X-Box Binding Protein 1, T7-tagged

• Cat.No.: XBP1-2906H
• Product Overview: Recombinant Human X-box binding protein 1 was expressed in E.Coli using anT7 tag at N-terminus. The molecular weight is 28695 Da.

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Description: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
• Sequences of amino acids: 1-261 aa
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
• Purity: 95%

Gene Information

• Gene Name: XBP1 X-box binding protein 1 [ Homo sapiens ]
• Synonyms: XBP1; X-box binding protein 1; XBP2; TREB5; X-box-binding protein 1; Tax-responsive element-binding protein 5; XBP-1
• Gene ID: 7494
• mRNA Refseq: NM_001079539
• Protein Refseq: NP_001073007
• MIM: 194355
• UniProt ID: P17861
• Chromosome Location: 22q12.1
• Pathway: Diabetes pathways; Protein processing in endoplasmic reticulum
• Function: DNA binding;protein dimerization activity; sequence-specific DNA binding; transcription factor activity; sequence-specific DNA binding transcription factor activity