XBP1

  • Official Full Name

    X-box binding protein 1
  • Overview

    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
  • Synonyms

    XBP1;X-box binding protein 1;XBP2;TREB5;XBP-1;X-box-binding protein 1;tax-responsive element-binding protein 5

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Rhesus macaque
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • His&GST
  • His
  • T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
XBP1-092H Recombinant Human XBP1 Protein, GST-HIS-tagged E.coli Human His&GST
XBP1-1341C Recombinant Chicken XBP1 Mammalian Cell Chicken His
XBP1-1570H Recombinant Human X-Box Binding Protein 1, His-tagged E.coli Human His
XBP1-18601M Recombinant Mouse XBP1 Protein Mammalian Cell Mouse His
XBP1-2906H Recombinant Human X-Box Binding Protein 1, T7-tagged E.coli Human T7
XBP1-30866TH Recombinant Human XBP1, T7 -tagged E.coli Human T7 Full L.
XBP1-5227R Recombinant Rhesus monkey XBP1 Protein, His-tagged Mammalian Cell Rhesus macaque His
XBP1-6607R Recombinant Rat XBP1 Protein Mammalian Cell Rat His
XBP1-9378Z Recombinant Zebrafish XBP1 Mammalian Cell Zebrafish His
XBP1-267HCL Recombinant Human XBP1 293 Cell Lysate HEK293 Human Non
XBP1-10220M Recombinant Mouse XBP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
XBP1-10220M-B Recombinant Mouse XBP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
XBP1-1571H Recombinant Human XBP1 protein, His-tagged E.coli Human His 167-261 aa
XBP1-5040R Recombinant Rhesus Macaque XBP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
XBP1-5040R-B Recombinant Rhesus Macaque XBP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Xbp1-592M Recombinant Mouse Xbp1 Protein, His&GST-tagged E.coli Mouse His&GST Met1-Leu267
XBP1-6263R Recombinant Rat XBP1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
XBP1-6263R-B Recombinant Rat XBP1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    XBP1 involved in several pathways and played different roles in them. We selected most pathways XBP1 participated on our site, such as Protein processing in endoplasmic reticulum,Non-alcoholic fatty liver disease (NAFLD),HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with XBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum DNAJC5AA,RAD23A,NPLOC4,PDIA4,UBE2D4,MARCH6,DNAJC5B,SEC24B,SEC23B,SEL1L2
    HTLV-I infection STAT5B,CREM,WNT9B,RANBP1,MAPK8,RRAS2,AKT2,PIK3CB,AKT1,TRP53
    Non-alcoholic fatty liver disease (NAFLD) AKT1,EIF2AK3,COX5A,NDUFS8,PKLR,IL6,NDUFB4,NDUFA10,NDUFS6,TRAF2

    Protein Function

    XBP1 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XBP1 itself. We selected most functions XBP1 had, and list some proteins which have the same functions with XBP1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZKSCAN3,CEBPG,JRK,LCOR,LYL1,NR2F1B,RARG,ZNF280A,SAP30L,HOXC13
    protein binding MTX2,CLTA,SF3B2,CNOT10,EPB41L1,PDE2A,NTSR1,AP1G1,KIAA0368,PAIP2
    transcription factor activity, sequence-specific DNA binding KAT7A,ARNT,NFE2L3,ZIC2,ZNF544,ARNTL1B,HEY1,NOTCH1,NFYC,WNT5A
    core promoter binding INSM1B,FOXO3,IRF9,HDAC4,MYBBP1A,ELK1,MYOG,REST,CCAR1,KDM3A
    protein heterodimerization activity ATF2,TPD52L1,ITGB1,HIST1H2BB,TPD52L2,DRAP1,MAFA,ENO2,PVALB,USF1
    enhancer sequence-specific DNA binding GATA1,TFAP2B,SOX11,LDB1,FOXN4,GATA4,SOX9,MYT1,HMGB2,ATF2
    RNA polymerase II regulatory region sequence-specific DNA binding PRDM15,SNAI1,PKNOX2,ETV7,CREB3L3,ATF5A,NKX2-1,SP5,GATA5,ARID5B
    protein homodimerization activity SNF8,CTBP1,CHKA,Flt3l,LHPP,PRMT8,STUB1,UGT1A7,NFKB1,NACC2
    protein kinase binding PKD1,TPX2,CAMK2N1,AP2A2,SKAP1,CDK5,PTPN6,LIMS1,TRIM22,NPM1

    Interacting Protein

    XBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XBP1.

    ATF6;CREBZF;CANX

    Resources

    References

    • Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    • van't Wout, EFA; van Schadewijk, A; et al. Function of monocytes and monocyte-derived macrophages in alpha(1)-antitrypsin deficiency. EUROPEAN RESPIRATORY JOURNAL 45:365-376(2015).

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