Recombinant Human WEE2 Protein (D2-H567), Tag Free

• Cat.No.: WEE2-0789H
• Product Overview: Recombinant Human GG-WEE2(D2-H567 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Protein Length: D2-H567
• Description: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: WEE2 WEE1 homolog 2 (S. pombe) [ Homo sapiens (human) ]
• Official Symbol: WEE2
• Synonyms: WEE1B
• Gene ID: 494551
• mRNA Refseq: NM_001105558
• Protein Refseq: NP_001099028
• MIM: 614084
• UniProt ID: P0C1S8