Recombinant Human WAS Protein (Leu39-Gly251), His tagged

• Cat.No.: WAS-5489H
• Product Overview: Recombinant human WAS (Leu39-Gly251) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Leu39-Gly251
• Description: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 24.67 kDa
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: WAS WASP actin nucleation promoting factor [ Homo sapiens (human) ]
• Official Symbol: WAS
• Synonyms: WAS; WASP actin nucleation promoting factor; THC; IMD2; SCNX; THC1; WASP; WASPA; actin nucleation-promoting factor WAS; eczema-thrombocytopenia; thrombocytopenia 1 (X-linked); wiskott-Aldrich syndrome protein
• Gene ID: 7454
• mRNA Refseq: NM_000377
• Protein Refseq: NP_000368
• MIM: 300392
• UniProt ID: P42768