Recombinant Human VSIR Protein, Avi/His-tagged

• Cat.No.: VSIR-21H
• Product Overview: Recombinant Human VSIR(Phe 33 - Ala 194) fused with Avi/His tag at the C-terminus was produced in HEK293.

Specification

• Description: Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
• Source: HEK293
• Species: Human
• Tag: His&Avi
• Predicted N Terminal: Phe 33
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Molecular Mass: The protein has a calculated MW of 20.8 kDa. As a result of glycosylation, the protein migrates as 35-45 kDa under reducing (R) condition, and 35-45 kDa under non-reducing (NR) condition (SDS-PAGE).
• Protein length: Phe 33 - Ala 194
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  No activity loss is observed after storage at:
  4-8 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.

Gene Information

• Gene Name: VSIR V-set immunoregulatory receptor [ Homo sapiens ]
• Official Symbol: VSIR
• Synonyms: B7H5; GI24; B7-H5; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha; V-domain Ig suppressor of T cell activation; V-set domain-containing immunoregulatory receptor; platelet receptor GI24; sisp-1
• Gene ID: 64115
• mRNA Refseq: NM_022153
• Protein Refseq: NP_071436
• MIM: 615608
• UniProt ID: Q9H7M9