Recombinant Human USP37 Protein (S2-L979), His tagged

• Cat.No.: USP37-0350H
• Product Overview: Recombinant Human 8His-TEV-GG- USP37(S2-L979 end) Protein was expressed in Insect cell.

Specification

• Description: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: S2-L979
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: USP37 ubiquitin specific peptidase 37 [ Homo sapiens (human) ]
• Official Symbol: USP37
• Synonyms: USP37; ubiquitin specific peptidase 37; ubiquitin specific protease 37; ubiquitin carboxyl-terminal hydrolase 37; KIAA1594; tmp_locus_50; ubiquitin thioesterase 37; deubiquitinating enzyme 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37; MGC117261
• Gene ID: 57695
• mRNA Refseq: NM_020935
• Protein Refseq: NP_065986
• UniProt ID: Q86T82