Recombinant Human UNC5B, Fc-tagged

• Cat.No.: UNC5B-31670TH
• Product Overview: Recombinant fragment of Human UNC5B fused at the C terminus to the Fc portion of Human IgG1; mwt: 80 kDa by SDS PAGE.

Specification

• Description: This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
• Protein length: 336 amino acids
• Conjugation: Fc
• Molecular Weight: 80.000kDa
• Source: HEK 293 cells
• Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
• Biological activity: Binds to Mouse and Human Netrin 1.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the unc-5 family.Contains 1 death domain.Contains 1 Ig-like (immunoglobulin-like) domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 2 TSP type-1 domains.Contains 1 ZU5 domain.

Gene Information

• Gene Name: UNC5B unc-5 homolog B (C. elegans) [ Homo sapiens ]
• Official Symbol: UNC5B
• Synonyms: UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2
• Gene ID: 219699
• mRNA Refseq: NM_001244889
• Protein Refseq: NP_001231818
• MIM: 607870
• Uniprot ID: Q8IZJ1
• Chromosome Location: 10q22.2
• Pathway: Apoptosis, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: netrin receptor activity; protein binding; receptor activity