Recombinant Human UMPS Protein, His-tagged

Cat.No. : UMPS-212H
Product Overview : Recombinant Human UMPS(1-480aa) fused with His tag at C-terminal was expressed in Insect cells.
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Species : Human
Source : Insect Cells
Tag : His
Protein Length : 1-480aa
Description : UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU.
Form : Liquid. In Phosphate Buffered Saline (pH 7.4).
Molecular Mass : 53kDa (486aa) 50-70kDa (SDS-PAGE under reducing conditions)
AA Sequence : MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ
IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML
EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA
DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP
LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG
RGIISAADRL EAAEMYRKAA WEAYLSRLGV HHHHHH
Purity : > 95% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Absorbance at 280nm)
Gene Name UMPS uridine monophosphate synthetase [ Homo sapiens ]
Official Symbol UMPS
Synonyms UMPS; uridine monophosphate synthetase; uridine 5-monophosphate synthase; orotate phosphoribosyl transferase and orotidine 5 decarboxylase; OPRTase; OMPdecase; UMP synthase; orotate phosphoribosyltransferase; orotidine 5-phosphate decarboxylase; OPRT;
Gene ID 7372
mRNA Refseq NM_000373
Protein Refseq NP_000364
MIM 613891
UniProt ID P11172

Not For Human Consumption!

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