Recombinant Human UL16 Binding Protein 2, His-tagged

• Cat.No.: ULBP2-6841H
• Product Overview: Recombinant human ULBP2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: ULBP2 belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2M urea, 0.2M NaCl, 2mM DTT.
• Molecular Mass: 24.3 kDa (216aa)
• Protein length: 26-216 aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLRDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKVVAM SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMS
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: ULBP2 UL16 binding protein 2 [ Homo sapiens ]
• Official Symbol: ULBP2
• Synonyms: ULBP2; UL16 binding protein 2; NKG2D ligand 2; RAET1H; N2DL-2; NKG2DL2; ALCAN-alpha; UL16-binding protein 2; retinoic acid early transcript 1H; retinoic acid early transcript 1 H; N2DL2
• Gene ID: 80328
• mRNA Refseq: NM_025217
• Protein Refseq: NP_079493
• MIM: 605698
• UniProt ID: Q9BZM5
• Chromosome Location: 6q25
• Pathway: Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem
• Function: MHC class I receptor activity