Recombinant Human UBR2 cell lysate

• Cat.No.: UBR2-1876HCL

Specification

• Species: Human
• Tag: Non
• Description: Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrates destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: UBR2 ubiquitin protein ligase E3 component n-recognin 2 [ Homo sapiens ]
• Official Symbol: UBR2
• Synonyms: UBR2; ubiquitin protein ligase E3 component n-recognin 2; C6orf133, chromosome 6 open reading frame 133; E3 ubiquitin-protein ligase UBR2; bA49A4.1; dJ392M17.3; KIAA0349; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II; C6orf133; dJ242G1.1; RP3-392M17.3; FLJ36357; MGC71112; DKFZp686C08114
• Gene ID: 23304
• mRNA Refseq: NM_001184801
• Protein Refseq: NP_001171730
• MIM: 609134
• UniProt ID: Q8IWV8
• Chromosome Location: 6p21.1
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: leucine binding; ligase activity; metal ion binding; ubiquitin-protein ligase activity; zinc ion binding