Recombinant Human UBB Protein (Met1-Gly75), N-10×­His-tagged

• Cat.No.: UBB-15H
• Product Overview: Recombinant Human UBB Protein (Met1-Gly75) with YADLREDPDRQDHHPGSGAQ at C-­terminus fused with N-10×­His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Met1-Gly75
• Description: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.
• Bio-activity: Bioassay data are not available.
• Molecular Mass: Predicted Molecular Mass: 13 kDa
  SDS-PAGE: 13 kDa, reducing conditions
• N-terminal Sequence Analysis: Ala
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Applications: Bioactivity
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  6 months from date of receipt, -20 to -70 centigrade as supplied.
  3 months, -20 to -70 centigrade under sterile conditions after opening.
• Storage Buffer: Supplied as a 0.2 μm filtered solution in PBS.
• Shipping: The product is shipped with dry ice or equivalent.

Gene Information

• Gene Name: UBB ubiquitin B [ Homo sapiens (human) ]
• Official Symbol: UBB
• Synonyms: UBB; ubiquitin B; HEL-S-50; polyubiquitin-B; epididymis secretory protein Li 50; polyubiquitin B
• Gene ID: 7314
• mRNA Refseq: NM_018955
• Protein Refseq: NP_061828
• MIM: 191339
• UniProt ID: P0CG47