Cat. No. :	TYR-222H
Description :	Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. Tyrosinase and melan A are the most commonly expressed melanoma markers and are found in approximately 80 to 100 per cent of cases. This antibody is of help in the identification of melanocytic tumors.
Source :	E. Coli.
Formulation :	Recombinant Human Tyrosinase protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
Solubility :	It is recommended to dilute the recombinant material in sterile 18 MO-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability :	Store undiluted at -20°C to -80 °C. Stable up to 12 months. Please avoid freeze-thaw cycles.
Purity :	On SDS-PAGE commassie blue stained gel, the recombinant protein shows a band at 64kda including GST.
Tag :	Non

Gene Name	TYR tyrosinase (oculocutaneous albinism IA) [ Homo sapiens ]
Synonyms	TYR; tyrosinase (oculocutaneous albinism IA); OCA1A; OCAIA; SHEP3; Tyrosinase;EC1.14.18.1; Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB
Gene ID	7299
mRNA Refseq	NM_000372
Protein Refseq	NP_000363
MIM	606933
UniProt ID	P14679
Chromosome Location	11q14-q21
Pathway	Betalain biosynthesis; Biosynthesis of alkaloids derived from shikimate pathway; Isoquinoline alkaloid biosynthesis; Melanogenesis; Metabolic pathways; Riboflavin metabolism; Tyrosine metabolism
Function	copper ion binding; metal ion binding; monooxygenase activity; monophenol monooxygenase activity; protein binding; protein heterodimerization activity