Recombinant Human TYRO3 Protein Tyrosine Kinase, GST-tagged, Active

• Cat.No.: TYRO3-254H
• Product Overview: Recombinant human TYRO3 (455-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 77 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 455-end a.a.
• Description: TYRO3 receptor protein tyrosine kinase together with AXL and MER form the AXL/TYRO3 family of receptor tyrosine kinases. Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, members of this family of receptor tryrosine kinases participate in cell adhesion. Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. TYRO3 is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumor cell lines.
• Sequence: 455-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: TYRO3 TYRO3 protein tyrosine kinase [ Homo sapiens ]
• Synonyms: TYRO3 protein tyrosine kinase; BYK; Brt; Dtk; RSE; Sky; Tif; FLJ16467; TYRO3; tyrosine-protein kinase receptor TYRO3; Tyro3 protein tyrosine kinase (sea-related receptor tyrosine kinase); DTK; EC 2.7.10.1; SKY; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase byk
• Gene ID: 7301
• mRNA Refseq: NM_006293
• Protein Refseq: NP_006284
• MIM: 600341
• UniProt ID: Q06418
• Chromosome Location: 15q15.1-q21.1
• Function: ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity