TYRO3
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Official Full Name
TYRO3 protein tyrosine kinase -
Overview
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] -
Synonyms
TYRO3;TYRO3 protein tyrosine kinase;BYK;Dtk;RSE;Sky;Tif;tyrosine-protein kinase receptor TYRO3;tyrosine-protein kinase DTK;tyrosine-protein kinase RSE;tyrosine-protein kinase SKY;tyrosine-protein kinase TIF;tyrosine-protein kinase byk
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Rat
- Zebrafish
- E.coli
- Sf9 Cells
- Mammalian Cells
- C-His
- HEK293
- GST
- His
- Flag&His
- Fc
- Non
- DDK&Myc
- Flag
- mFc
- Fc&His
- Avi&Fc&His
Involved Pathway
TYRO3 involved in several pathways and played different roles in them. We selected most pathways TYRO3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TYRO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TYRO3 has several biochemical functions, for example, ATP binding,phosphatidylinositol 3-kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYRO3 itself. We selected most functions TYRO3 had, and list some proteins which have the same functions with TYRO3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PRKACG,UBE2KA,NLRP2,KIF17,ACACB,ENTPD8,HSP70L,BTK,UBA7,FLT3 |
| protein heterodimerization activity | SDCBP,MAP3K7,HEYL,CHUK,HEXB,NFKB1,PVALB,MAFGA,SPTA1,ADRA1B |
| phosphatidylinositol 3-kinase binding | IRS4,CALM3,IRS1,CALM2,DAB1,INSRA,IRS2,PDGFRB,FYN,INSRB |
| virus receptor activity | GPR172B,RPSA,HSPA1B,TNFRSF14,GYPA,SCARB1,HSPA1A,EFNB3,DPP4,HTR2A |
| protein binding | STK38,KCNJ3,PLCG2,SUN2,C12orf68,FOXM1,MALT1,HNRNPH1,PCID2,ZBTB2 |
| receptor signaling protein tyrosine kinase activity | LYN,SYK,ERBB2,INSR,EGFR,EGFRA,ERBB3B,KIT,ERBB4,KITA |
| transmembrane receptor protein tyrosine kinase activity | NTRK3,FLT4,ERBB4,NPTN,EPHB2B,EPHA2A,LTK,DDR1,TEK,NTRK1 |
| protein tyrosine kinase activity | PTK6B,SHC1,CSK,PTK7,PTK2BB,MATK,NTRK3A,INSRA,ABL1,TTN |
Interacting Protein
TYRO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYRO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYRO3.
KRTAP5-9;KRTAP10-7;KRTAP10-8;KRTAP10-9;KRT40;MDFI
Resources
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References
- Nguyen, KQN; Tsou, WI; et al. Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25737-25749(2014).
- Shibata, T; Habiel, DM; et al. Axl Receptor Blockade Ameliorates Pulmonary Pathology Resulting from Primary Viral Infection and Viral Exacerbation of Asthma. JOURNAL OF IMMUNOLOGY 192:3569-3581(2014).
