Recombinant Human TYMP, His-tagged

• Cat.No.: TYMP-30403TH
• Product Overview: Recombinant full length Human Thymidine Phosphorylase with an N terminal His tag; 493aa, 51.3kDa inclusive of tag.

Specification

• Description: This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.
• Protein length: 472 amino acids
• Conjugation: HIS
• Molecular Weight: 51.300kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ

Gene Information

• Gene Name: TYMP thymidine phosphorylase [ Homo sapiens ]
• Official Symbol: TYMP
• Synonyms: TYMP; thymidine phosphorylase; ECGF1, endothelial cell growth factor 1 (platelet derived) , MNGIE; gliostatin
• Gene ID: 1890
• mRNA Refseq: NM_001113755
• Protein Refseq: NP_001107227
• MIM: 131222
• Uniprot ID: P19971
• Chromosome Location: 22q13
• Pathway: Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Fluoropyrimidine Activity, organism-specific biosystem
• Function: growth factor activity; platelet-derived growth factor receptor binding; pyrimidine-nucleoside phosphorylase activity; thymidine phosphorylase activity; transferase activity, transferring pentosyl groups