TYMP
-
Official Full Name
thymidine phosphorylase -
Overview
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012] -
Synonyms
TYMP;thymidine phosphorylase;TP;ECGF;ECGF1;MNGIE;MEDPS1;MTDPS1;PDECGF;hPD-ECGF;tdRPase;gliostatin
Recombinant Proteins
- Human
- Mouse
- Rat
- Sf21 Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Non
- His
- GST
- His&T7
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TYMP involved in several pathways and played different roles in them. We selected most pathways TYMP participated on our site, such as Bladder cancer,Drug metabolism - other enzymes,Fluoropyrimidine Activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fluoropyrimidine Activity | DPYS,CES1,DHFR,DPYD,SLC22A7,UPP2 |
| Bladder cancer | ERBB2,CXCL8,THBS1,CDH1,UPK3A,RASSF1,NRAS,MDM2,EGF,MYC |
| Pyrimidine catabolism | PROZA,UPP2,DPYS,DPYDA.1,DPYD |
| Metabolism | AZIN1B,GSTK1,ACAD11,SLC25A2,MED8,NDUFAF2,SGMS2,PDK2,NUDT15,NOSTRIN |
| Metabolic pathways | NOS1,ITPKB,DNMT3,PTGS2B,COQ3,GALM,ALOX5,ANPEPB,ALG9,MPST |
| Metabolism of nucleotides | DUT,NUDT15,ADSSL1,NUDT1,ADK,DTYMK,DCK,DHODH,GRX2,ADAL |
| Pyrimidine metabolism | POLR3K,POLR3D,POLR2F,CMPK,POLR2EB,POLR2J2,ENTPD8,UCK2A,CDA,POLR2K |
| Drug metabolism - other enzymes | CES1,UCKL1,UGT1A7,IMPDH1B,GUSB,NAT2,UGT1A9,CES1C,TPMT,UCK2B |
Protein Function
TYMP has several biochemical functions, for example, growth factor activity,phosphorylase activity,platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYMP itself. We selected most functions TYMP had, and list some proteins which have the same functions with TYMP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | EGF,PPBP,TGFA,IGF1,OGN,FGF12B,HGF,FGF9,GDF11,FGF12A |
| phosphorylase activity | PYGMA,PYGMB,MTAP |
| transferase activity, transferring pentosyl groups | PNP4A,PNP5B,PNP6 |
| platelet-derived growth factor receptor binding | PDGFB,PDGFRB,IL1R1,FIGF,Pdgfa&Pdgfb,PTPRJ,PDGFD,ITGB3,PTEN,PDGFAA |
Interacting Protein
TYMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYMP here. Most of them are supplied by our site. Hope this information will be useful for your research of TYMP.
Cdk1
Resources
Research Area
Endothelial Cell MarkersEnzymes Secreted by Endothelial Cells
Other Cytokines & Receptors
Related Services
Related Products
References
- Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
