Recombinant Human TXNRD1 Protein, MYC/DDK-tagged

• Cat.No.: TXNRD1-2969H
• Product Overview: Recombinant Human TXNRD1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TXNRD1 thioredoxin reductase 1 [ Homo sapiens ]
• Official Symbol: TXNRD1
• Synonyms: GRIM-12; TR; TR1; TRXR1; TXNR
• Gene ID: 7296
• mRNA Refseq: NM_001093771
• Protein Refseq: NP_001087240
• MIM: 601112
• UniProt ID: Q16881