Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A

• Cat.No.: TNFRSF1A-1577H
• Product Overview: Recombinant Human TNF receptor (P55) extracellular domain is produced in genetically engineeredSpodoptera frugiperda insect cells (Sf9)infected with recombinant viruses, and purified by sequential chromatography.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Non
• Description: TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis.
• Isotype: N/A.
• Purity: Over 80% pure. Three bands are observed by SDS gel electrophoresis, however, a single band is observed after glycosidase treatment, indicating heterogeneity in the sugar portion of this glycoprotein.
• Formulation: 10 mM Hepes, pH 7.0. Concentration: 1.0 mg protein/ml.
• Biological Activity: Binding of the ligand TNF was demonstrated by receptor binding competition of binding with radioactive TNF.
• Stability: At least 2 months at -80°C.
• Storage: Store at -80°C.

Gene Information

• Gene Name: TNFRSF1A tumor necrosis factor receptor superfamily, member 1A [ Homo sapiens ]
• Synonyms: TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; MGC19588; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor
• Gene ID: 7132
• mRNA Refseq: NM_001065
• Protein Refseq: NP_001056
• MIM: 191190
• UniProt ID: P19438
• Chromosome Location: 12p13.2
• Pathway: Adipocytokine signaling pathway; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytokine-cytokine receptor interaction; MAPK signaling pathway; MAPK signaling pathway; Apoptosis
• Function: protein complex binding; receptor activity; tumor necrosis factor receptor activity