Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 13b, His-tagged

• Cat.No.: TNFSF13B-395H
• Product Overview: Recombinant Human TNFSF13Bis a protein composed of 18-20 kDa, 151 amino residues and it Contains a 10-His-tagat the N-terminal end and is purified by sequential chromatography.

Specification

• Cat. No.: TNFSF13B-395H
• Description: TNFSF13B issingle-pass type II membrane protein. It belongs to the tumor necrosis factorfamily. TNFSF13B is abundantly expressed in peripheral blood Leukocytes andis specifically expressed in monocytes and macrophages. TNFSF13B is alsofound in the spleen, lymph node, bone marrow, T-cells and dendritic cells.
• Source: Nicotianabenthamiana. Produced by transient expression of human recombinan HumanTNFSF13B innon-transgenic plants.
• Species: Human
• Form: Recombinan humanBAFF is lyophilized from 20 mM PBS buffer pH 7 and 0.2 M NaCl.
• Purity: > 97% by SDS-PAGEgel
• M.W: 18-20 kDa
• Endotoxin Level: < 0.04 EU/μgprotein (LAL method)
• Sequence: HHHHHHHHHHAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKET GYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDEL QLAIPRENAQISLDGDVTFFGALKLL
• p.I: 6.03
• Extinction coeff: Abs 0.1% (1g/l) =0.791
• Reconstitution Recommendation: Lyophilized proteinshould be reconstituted in water to a concentration of 25-50 ng / μl.
• Biological Activity: ≤ 50 ng/mL. Theactivity is determined by dose-dependeant stimulation of proliferation B cellfrom Human PBMC. Cell proliferation was measured by MTT method. Activityresults may vary with PBMC donors.
• Storage: This lyophilizedpreparation is stable at 2-8ºC. For long storage should be kept at -20ºC. Avoidrepeted freeze-thaw cycles.
• OfficialSymbol: TNFSF13B
• Pathways: Cytokine-cytokinereceptor interaction; Intestinal immune network for IgA production;Rheumatoid arthritis

Gene Information

• Gene Name: TNFSF13B tumor necrosis factor(ligand) superfamily, member 13b [ Homo sapiens ]
• Synonyms: TNFSF13B; tumor necrosis factor (ligand) superfamily,member 13b; DTL;BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; tumor necrosisfactor ligand superfamily member 13B; delta BAFF; Delta4 BAFF;OTTHUMP00000018691; B-lymphocyte stimulator; B-cell-activating factor; ApoLrelated ligand TALL-1; TNF homolog that activates apoptosis; dendriticcell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNFand ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand)superfamily, member 20; Tumor necrosis factor ligand superfamily member 13B; Dendriticcell-derived TNF-like molecule
• Gene ID: 10673
• mRNA Refseq: NM_001145645
• Protein Refseq: NP_001139117
• MIM: 603969
• UniProt ID: Q9Y275
• Chromosome Location: 13q32-q34
• Function: cytokine activity;receptor activity; protein binding; tumor necrosis factor receptor binding